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Cover: Biology for the AP® Course, 2nd Edition by James Morris; Domenic Castignetti; John Lepri; Rick Relyea
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Biology for the AP® Course

Second Edition| ©2026 James Morris; Domenic Castignetti; John Lepri; Rick Relyea

Biology for the AP® Course, Second Edition is the only major AP® Biology program built entirely for the AP® course. Unlike college texts adapted for high school, this text was written from the ground up to align with the latest 2025-2026 Course and Exam Description (CED), su...

Biology for the AP® Course, Second Edition is the only major AP® Biology program built entirely for the AP® course. Unlike college texts adapted for high school, this text was written from the ground up to align with the latest 2025-2026 Course and Exam Description (CED), support the Big Ideas, and meet the needs of AP® students and teachers alike.

This trusted second edition adds even more AP® practice questions, new Unit-Opening Essays, a full Unit 0 on foundational skills, and end-of-unit Illustrative Examples that connect concepts to real-world science. The highly readable text balances accessibility with rigor—carefully scaffolding learning to help all students succeed with college-level biology.

Throughout the program, science practices are seamlessly integrated into the student friendly narrative along with visuals, activities, and assessments, helping students build the skills they need for the exam and beyond. Every element—from the AP® Exam Tips to the in-text tutorials and Practicing Science boxes—was crafted by a team of AP® experts, including former Chief Readers and longtime educators.

With powerful digital tools in Achieve—including assignable assessments, adaptive quizzing, and rich media like animations, simulations, and podcasts—this program equips teachers to deliver a complete, engaging, and effective AP® Biology experience.

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Hardcover $133.98

ISBN:9781319584566

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ISBN:9781319605803

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Cover: Biology for the AP® Course, 2nd Edition by James Morris; Domenic Castignetti; John Lepri; Rick Relyea

From Future to Foundation. Get AP® Biology Ready.

Biology for the AP® Course, Second Edition is the only major AP® Biology program built entirely for the AP® course. Unlike college texts adapted for high school, this text was written from the ground up to align with the latest 2025-2026 Course and Exam Description (CED), support the Big Ideas, and meet the needs of AP® students and teachers alike.

This trusted second edition adds even more AP® practice questions, new Unit-Opening Essays, a full Unit 0 on foundational skills, and end-of-unit Illustrative Examples that connect concepts to real-world science. The highly readable text balances accessibility with rigor—carefully scaffolding learning to help all students succeed with college-level biology.

Throughout the program, science practices are seamlessly integrated into the student friendly narrative along with visuals, activities, and assessments, helping students build the skills they need for the exam and beyond. Every element—from the AP® Exam Tips to the in-text tutorials and Practicing Science boxes—was crafted by a team of AP® experts, including former Chief Readers and longtime educators.

With powerful digital tools in Achieve—including assignable assessments, adaptive quizzing, and rich media like animations, simulations, and podcasts—this program equips teachers to deliver a complete, engaging, and effective AP® Biology experience.

Features

Biology for the AP® Course, Second Edition gives teachers a complete and cohesive program designed specifically for the AP® Biology course. Every feature was intentionally crafted to support CED alignment, build student confidence, and make AP-level science more accessible and engaging. Now even more robust in its second edition, the program combines strong pedagogy, powerful visuals, and effective digital tools to drive classroom success.

  • Truly Built for AP®: The only major textbook written from the ground up for the AP® Biology CED—not adapted from a college text.
  • Modular and Manageable: Organized in short, scaffolded modules that support flexible pacing and student comprehension.
  • Readability with Rigor: Clear, approachable explanations help students at all levels tackle college-level content with confidence.
  • AP® Practice Throughout: End-of-module and end-of-unit AP® Practice Questions plus a full-length cumulative exam build test readiness from day one.
  • Skill Development at the Core: Practicing Science boxes, in-text tutorials, and “Analyzing Statistics and Data” features reinforce math, data analysis, and scientific reasoning.
  • Engaging Visuals: Visual Synthesis figures and annotated diagrams help students visualize biological systems and relationships.
  • Real-World Connections: Unit-opening essays and end-of-unit Illustrative Examples encourage students to apply what they’ve learned.
  • Teacher Support Built In: The full wraparound Teacher’s Edition includes pacing guides, point-of-use teaching tips, differentiated activities, assessment support, and extra AP® practice—all written by experienced AP® educators.
  • Robust Digital Platform: Achieve includes assignable questions with targeted feedback, adaptive quizzing with LearningCurve, simulations, 3D animations, and science skill tutorials—offering flexibility and depth for any classroom.

New to This Edition

Trusted by teachers nationwide, Biology for the AP® Course returns in its second edition with smart, targeted updates that reflect classroom feedback and evolving expectations from the College Board. While the structure and clarity that made the first edition so successful remain, the second edition introduces thoughtful enhancements to better support student engagement, pacing, and AP® exam readiness.

  • A New Unit 0: Foundations helps students build confidence in data analysis, graphing, and scientific reasoning from the very start of the course—laying the groundwork for success in AP® Biology.
  • Unit-Opening Essays now appear at the start of each unit to spark curiosity and connect course content to real-world biological phenomena.
  • End-of-Unit Illustrative Examples offer engaging case studies that extend and apply key concepts, encouraging deeper thinking and synthesis.
  • Expanded AP® Practice throughout the book—including new practice questions tied directly to each tutorial—provides even more opportunities for students to practice the skills and content they’ll encounter on exam day.
  • New Enrichment Modules offer post-exam learning on body systems, sensory biology, and viruses—with optional end-of-year projects and teacher resources to extend key concepts.
  • New Student Resource: Strive for a 5 is now available to reinforce key concepts, guide review, and provide targeted AP® exam preparation through a mix of study tools and practice questions.
  • Enhanced Digital Resources in Achieve, including adaptive LearningCurve quizzes and more assignable assessments, further personalize instruction and support all learners.

These updates build on a program that is already uniquely designed for the AP® Biology course—and now more effective than ever.

"Students find the textbook thorough yet easy to understand. I have many students who rely on this alone to help them learn material for the course."

"We are very happy with the text overall. The students find it very readable and the content is what is needed for the course (not a lot of extra stuff)."

"I love the alignment to the CED and the reading guides for each module."

"It is exactly what my students need to know and at the correct level. Also the practice AP questions throughout and the helpful tips specific to the exam are amazing."

"Getting students to use any textbook is a struggle, but this is the most approachable version of an AP Bio text I have used."

"The text is on target. Modules are clear and concise. It does an excellent job supporting the topics in the AP Biology program."

Based on anonymous teacher reviews of the first edition. These quotes come from AP® Biology educators who reviewed and used the program—feedback that directly informed the development of this second edition.

Cover: Biology for the AP® Course, 2nd Edition by James Morris; Domenic Castignetti; John Lepri; Rick Relyea

Biology for the AP® Course

Second Edition| ©2026

James Morris; Domenic Castignetti; John Lepri; Rick Relyea

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Cover: Biology for the AP® Course, 2nd Edition by James Morris; Domenic Castignetti; John Lepri; Rick Relyea

Biology for the AP® Course

Second Edition| 2026

James Morris; Domenic Castignetti; John Lepri; Rick Relyea

Table of Contents

Unit 0: Foundations

Module 01: Introduction

Module 02: Scientific Inquiry

Module 03: Visual Representations

Tutorial 1: Graphing

Illustrative Example: The Extinction of the Dinosaurs

Unit 1: Chemistry of Life

Module 1: Elements of Life

Module 2: Structure of Water and Hydrogen Bonding

Module 3: Carbohydrates and Lipids

Module 4: Nucleic Acids

Module 5: Proteins

Tutorial 2: Statistics

Illustrative Example: Luck and Penicillin

Unit 1 AP Practice Questions

Unit 2: Cells

Module 6: An Introduction to the Cell

Module 7: Cell Structure and Function

Module 8: Cell Size

Module 9: Plasma Membrane

Module 10: Mechanisms of Membrane Transport

Module 11: Osmosis, Tonicity, and Osmoregulation

Module 12: Origin of Compartmentalization and the Eukaryotic Cell

Illustrative Example: Plant–Fungal Associations

Unit 2 AP Practice Questions

Unit 3: Cellular Energetics

Module 13: Cellular Energy

Module 14: Enzymes and Environmental Impact on Enzyme Function

Module 15: Photosynthesis I: Overview

Module 16: Photosynthesis II: Biochemistry and Evolution

Module 17: Cellular Respiration I: Overview

Module 18: Cellular Respiration II: Biochemistry

Illustrative Example: A Photosynthetic Salamander

Unit 3 AP Practice Questions

Unit 4: Cell Communication and Cell Cycle

Module 19: Cell Communication

Module 20: Introduction to Signal Transduction

Module 21: Signal Transduction Pathways

Module 22: Feedback

Module 23: Cell Cycle

Module 24: Regulation of Cell Cycle

Illustrative Example: Cell Signaling and Cancer

Unit 4 AP Practice Questions

Unit 5: Heredity

Module 25: Meiosis and Genetic Diversity

Module 26: Mendelian Genetics

Tutorial 3: Probability

Module 27: Non-Mendelian Genetics

Module 28: Environmental Effects on Phenotypes

Illustrative Example: Living in a Lonely and Scary World

Unit 5 AP Practice Questions

Unit 6: Gene Expression and Regulation

Module 29: DNA and RNA Structure and Function

Module 30: DNA Replication

Module 31: Transcription and RNA Processing

Module 32: Translation

Module 33: Regulation of Gene Expression

Module 34: Cell Specialization and Development

Module 35: Mutations

Module 36: Biotechnology

Illustrative Example: CRISPR Scissors

Unit 6 AP Practice Questions

Unit 7: Evolution and Natural Selection

Module 37: Introduction to Evolution and Natural Selection

Module 38: Natural and Artificial Selection

Module 39: Population Genetics

Module 40: Hardy–Weinberg Equilibrium

Module 41: Evidence of Common Ancestry and Evolution

Module 42: Continuing Evolution

Module 43: Phylogeny

Module 44: Speciation

Module 45: Variation in Populations

Module 46: Origins of Life on Earth

Illustrative Example: The Anthropocene

Unit 7 AP Practice Questions

Unit 8: Ecology

Module 47: Responses to the Environment

Module 48: Energy Flow through Ecosystems

Module 49: Population Ecology

Module 50: Effect of Density on Populations

Tutorial 4: Rate and Growth in Populations Ecology

Module 51: Community Ecology

Module 52: Biodiversity

Module 53: Disruptions in Ecosystems

Illustrative Example: Impacts of Salt on Freshwater Ecosystems

Unit 8 AP Practice Questions

Cumulative AP Biology Practice Exam

Enrichment Modules

Enrichment Module A: The Nervous, Endocrine, and Immune Systems

Enrichment Module B: Animal Sensory Systems

Enrichment Module C: Viruses


Glossary / Glosario

Answers to Concept Check, Review, and Tutorial Practice Questions

The Periodic Table of the Elements

Cover: Biology for the AP® Course, 2nd Edition by James Morris; Domenic Castignetti; John Lepri; Rick Relyea

Biology for the AP® Course

Second Edition| 2026

James Morris; Domenic Castignetti; John Lepri; Rick Relyea

Find Your Rep

Authors

Headshot of James Morris

James Morris

James Morris is professor of biology at Brandeis University. He has taught a wide variety of courses for majors and non-majors, including introductory biology, evolution, genetics and genomics, epigenetics, comparative vertebrate anatomy, and a first-year seminar on Darwin’s On the Origin of Species. He is the recipient of numerous teaching awards from Brandeis and Harvard. His research focuses on the field of epigenetics and makes use of the fruit fly Drosophila melanogaster as a model organism. Dr. Morris received a PhD in genetics from Harvard University and an MD from Harvard Medical School. He was a Junior Fellow in the Society of Fellows at Harvard University and a National Academies Education Fellow and Mentor in the Life Sciences. He is an author of the college-level introductory biology textbook Biology: How Life Works and is a regular contributor to The American Biology Teacher. He has also served as a reader and participated in standard setting for the AP® Biology exam.


Headshot of Domenic Castignetti

Domenic Castignetti

Domenic Castignetti is professor emeritus of biology at Loyola University Chicago. During his 37 years at Loyola, he taught many courses, including the introductory biology two-semester course, general microbiology, microbial physiology, and biochemistry. He was awarded Loyola University’s Master Teacher of the College of Arts and Sciences Award and received the first Faculty/Staff Member of the Year Award from the Student Government Association. Dr. Castignetti received an MS from Colorado State University and a PhD in microbial ecology and physiology from the University of Massachusetts Amherst. His research, conducted with undergraduate and graduate students, focused on the microbiology and biochemistry of soil microorganisms. He has been associated with the AP® Biology program since 2003 and has served as a reader, table leader, and member of the Development Committee. He was chief reader for the AP® Biology exam for 5 years. He currently serves as an Adjunct Professor at Middlesex Community College in Bedford, Massachusetts, where he has taught microbiology and biology for non-majors.


Headshot of John Lepri

John Lepri

John Lepri is Professor Emeritus of Biology and Faculty Fellow in the Lloyds International Honors Program at the University of North Carolina at Greensboro. He has taught courses in introductory biology, biological clocks, and animal physiology. His research focused on hormones and pheromones that coordinate reproduction in mammals. Dr. Lepri earned a BS in zoology and psychology from the University of Michigan, and a PhD in zoology from North Carolina State University. His professional activities have included teacher preparation programs for high school science teachers. Dr. Lepri has worked with College Board and Educational Testing Service for more than 25 years, including 5 years as chief reader for the AP® Biology exam.


Headshot of Rick Relyea

Rick Relyea

Rick Relyea  is the William J. Rucker Professor in Fisheries and Wildlife at the University of Missouri–Columbia (Mizzou). He received a BS in environmental forest biology from the SUNY College of Environmental Science and Forestry, an MS in wildlife management from Texas Tech University, and a PhD in ecology and evolution from the University of Michigan. He has authored more than 200 scientific articles and presented research seminars throughout the world. Dr. Relyea was a professor at the University of Pittsburgh for 15 years, where he was named the Chancellor’s Distinguished Researcher and received the Tina and David Bellet Teaching Excellence Award. In 2014, he moved to Rensselaer Polytechnic Institute to direct the Darrin Fresh Water Institute. In 2025, Rick moved to Mizzou to be the founding director of the Johnny Morris Institute of Fisheries, Wetlands, and Aquatic Systems. Rick has a strong interest in high school education, including hosting high school science teachers who conduct research in his laboratory. He is the author of the college textbook Ecology: The Economy of Nature, and co-author of Environmental Science for the AP® Course, which is also published by BFW publishers.

Cover: Biology for the AP® Course, 2nd Edition by James Morris; Domenic Castignetti; John Lepri; Rick Relyea

Biology for the AP® Course

Second Edition| 2026

James Morris; Domenic Castignetti; John Lepri; Rick Relyea

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Teacher's Edition for Biology for the AP® Course

James Morris; Domenic Castignetti; John Lepri; Rick Relyea | Second Edition | ©2026 | ISBN:9781319605919
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Cover: Biology for the AP® Course, 2nd Edition by James Morris; Domenic Castignetti; John Lepri; Rick Relyea

Biology for the AP® Course

Second Edition| 2026

James Morris; Domenic Castignetti; John Lepri; Rick Relyea

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Cover: Environmental Science for the AP® Course, 4th Edition by Andrew Friedland; Rick Relyea

Environmental Science for the AP® Course

Andrew Friedland; Rick Relyea | Fourth Edition | 2023 | ISBN:9781319409289

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